Aims

The InterLACE project will undertake international cross-cohort research using existing longitudinal studies on women's health from ten different countries. We will investigate the relationship of reproductive health, from menarche to menopause, with cardiovascular disease (CVD) and Type 2 diabetes mellitus (T2DM) outcomes later in life. This cross-cultural study aims to:

  • Identify trajectories for reproductive health, formed by the relationships between markers, that best characterize lifetime reproductive health;
  • Investigate the relationship of markers and trajectories of reproductive health with subsequent risk of CVD and T2DM;
  • Examine how the effects of reproductive health vary due to culture, lifestyle, social and policy environments in different nations.

By using individual data from more than 230 000 participants, InterLACE provides sufficient statistical power to enable a comprehensive and detailed analysis of the role of reproductive health.

Translational outcomes from InterLACE can provide insights on the causal pathways for CVD and T2DM; and will expand and strengthen the evidence base to inform policy, for instance in the timing and targeting of preventative health strategies.